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Knee Pain and Knee Replacement (Adults)

  
Imaging in Knee Pain

Please note for most knee pain:

  • Do not routinely request MRIs from a primary care setting in non-traumatic knee pain
  • Unless presence of red flags (see red flag sections of pathways)
  • Most red flags will require referral to A&E or urgent orthopaedic referral therefore requesting imaging from primary care may not be appropriate (see pathways)
  • Unless the patient has a red flag, most knee pain pathways require a period of conservative management and referral only on non-resolution onto physio or MSK triage services (see detail for each pathway attached)

Common findings on knee MRIs in asymptomatic population (median age 44 years):

  • Meniscal tears (30%)
  • Cartilage and bone marrow abnormalities of patellofemoral joint (48-57%)
  • Moderate and severe cartilage lesions (19-31%)
  • Moderate and severe bone marrow oedema (19-31%)

UHCW knee MRI retrospective evaluation (follow link)

  • 4466 knee MRIs performed in 1 year period – 71% requested from primary care
  • 55% diagnosed with OA
  • 43% diagnosed with meniscal tear
  • < 50% were reviewed in secondary care
  • 15% underwent surgery at UHCW

Key findings

  • Most patients can be managed successfully without the need for operative intervention, highlighting the impact of non-operative interventions
  • 2/3rds of patients reviewed in primary care did not have an outpatients appointment in secondary care, highlighting that the majority of patients with knee pain can be managed successfully in primary care
  • OA was the most common diagnosis, however only 38% of these patients had an X-ray before the MRI scan. This implies thousands of MRI scans could have been avoided per year if an X-ray was performed

 

Referral for Primary Hip Replacement (Prior Approval)

Referral for Primary Hip Replacement

Prior Approval from the Integrated Care Board (ICB) will be required before any treatment proceeds in secondary care unless an alternative contract arrangement has been agreed with the ICB that does not necessitate the requirement of prior approval before treatment

Background

This policy applies only to elective primary hip or knee replacement for osteoarthritis

The majority of patients with osteoarthritis (OA) of the hip or knee can initially be managed adequately in primary and intermediate care by following the NICE Clinical Guideline 226 (2022) and Quality Standard 87 (2015) for care and management of OA

Indication

The most common indication for elective primary total knee replacement (TKR) is degenerative arthritis (osteoarthritis) of the joint

Other indications include rheumatoid arthritis, osteonecrosis and other types of inflammatory arthritis

Adults aged 45 or over can be diagnosed with OA clinically, without investigations if they have activity-related joint pain and any morning joint stiffness lasts no longer than 30 minutes. Primary or intermediate care x-ray may not be necessary as part of routine investigations

TKR with resurfaced patella

The ICB has reviewed NICE (NG157) guideline and wider literature via PubMed of the evidence for clinical and cost effectiveness of patellar resurfacing as part of primary TKR

The ICB has concluded that there is an overall financial benefit to patellar resurfacing, with patients more likely to need revisions, and seek more primary and secondary care appointments, where resurfacing has not taken place

On this basis, the decision as to whether Patellar resurfacing as part of primary TKR should take place is to be made during the primary TKR operation by the treating clinical team

Eligibility Criteria

Referral for specialist assessment can be considered for patients who meet all the following criteria 1-6:

1. Patient experiences joint symptoms (pain, stiffness and reduced function) that have a substantial impact on their quality of life defined as interfering with their activities of daily living or their ability to sleep

2. Patient has been offered at least the core (non-surgical) treatment options recommended by NICE NG226;

Advise people with osteoarthritis where they can find further information on:

  • Osteoarthritis and how it develops (including flares and progression over time), and information that challenges common misconceptions about the condition
  • Activity and therapeutic exercise tailored to their needs appropriate to age, comorbidity, pain severity or disability. Exercise should include local muscle strengthening and general aerobic fitness
  • Managing their symptoms
  • How to access additional sources of information and support after consultations, such as peer-to-peer support and support groups
  • Benefits and limitations of treatment

Referral to a recognised weight management programme for patients who are overweight or obese to improve outcomes

Evidence shows that lower BMIs have better surgical outcomes and therefore, patients who are overweight and obese must be offered support and interventions to lose weight and those who are obese must be offered a recognised weight management programme. This should be documented

All overweight and obese patients will be reviewed pre-operatively by the surgeon to ascertain medical fitness for surgery

Patient specific factors (including age, sex, smoking, obesity and co-morbidities) should not be barriers for surgery, however patients who smoke should be advised to attempt to stop smoking at least 4 weeks before surgery to reduce the risk of surgical and post-surgery complications

3. Joint symptoms are refractory to non-surgical treatments listed below including where appropriate; analgesia, steroid injections, local heat and cold therapy

4. Patients have a right to be fully informed about this procedure

As part of this process, clinicians should engage the patients (or their carers) in shared decision making about alternative management and the risks and benefits of surgery

5. Patient has confirmed they wish to have surgery

6. Any underlying medical conditions have been investigated and the patient’s condition has been optimised

Further advice and support

Currently some of this information is available on national websites, such as Arthritis UK (Osteoarthritis | Arthritis UK) however it has not been standardised in any way

Each hospital should have its own locally written information to distribute to patients in clinic. This local information may differ between centres, reflecting local practice, but there is no national standard for this information

The ICB expectation is that the information provided to patients includes the following as a minimum:

  • Agree individualised self-management strategies with the person with osteoarthritis
  • Manual therapy (such as manipulation, mobilisation or soft tissue techniques) should only be considered for people with hip or knee osteoarthritis and alongside therapeutic exercise
  • If discussing manual therapy, explain to people with osteoarthritis that there is not enough evidence to support its use alone for managing osteoarthritis
  • Devices – Consider walking aids (such as walking sticks) for people with lower limb osteoarthritis. Do not routinely offer insoles, braces, tape, splints or supports to people with osteoarthritis unless:

there is joint instability or abnormal biomechanical loading and

therapeutic exercise is ineffective or unsuitable without the addition of an aid or device and

the addition of an aid or device is likely to improve movement and function

Pharmacological management

If pharmacological treatments are needed to manage osteoarthritis, use them alongside non-pharmacological treatments and to support therapeutic exercise and at the lowest effective dose for the shortest possible time

Offer a topical non-steroidal anti-inflammatory drug (NSAID) to people with knee osteoarthritis

Consider a topical NSAID for people with osteoarthritis that affects other joints

If topical medicines are ineffective or unsuitable, consider an oral NSAID for people with osteoarthritis and take account of:

potential gastrointestinal, renal, liver and cardiovascular toxicity

any risk factors the person may have, including age, pregnancy, current medication and comorbidities

Offer a gastroprotective treatment (such as a proton pump inhibitor) for people with osteoarthritis while they are taking an NSAID

Do not routinely offer paracetamol or weak opioids unless they are only used infrequently for short-term pain relief and all other pharmacological treatments are contraindicated, not tolerated or ineffective

Explain to people with osteoarthritis that there is no strong evidence of benefit for paracetamol

For more information about opioids, see NICE’s guideline on medicines associated with dependence or withdrawal symptoms

Do not offer glucosamine or strong opioids to people to manage osteoarthritis.

If the person with osteoarthritis asks about glucosamine or strong opioids, explain that there is no strong evidence of benefit for glucosamine and the risks of strong opioids outweigh the benefits

Review with the person whether to continue treatment. Base the frequency of reviews on clinical need

Intra-articular injections: Do not offer intra-articular hyaluronan injections to manage osteoarthritis. Consider intra-articular corticosteroid injections when other pharmacological treatments are ineffective or unsuitable, or to support therapeutic exercise. Explain to the person that these only provide short-term relief (2 to 10 weeks)

Patients who smoke should be advised to attempt to stop smoking at least 4 weeks before surgery to reduce the risk of surgical and post-surgery complications

For patients who DO NOT meet the eligibility criteria, the ICB will only consider funding the treatment if an Individual Funding Request (IFR) detailing the patient’s clinical presentation is submitted to the ICB

6. Guidance/References

https://www.nice.org.uk/guidance/ng157/resources/joint-replacement-primary-hip-knee-and-shoulder-pdf-66141845322181

https://www.nice.org.uk/guidance/ng226/resources/osteoarthritis-in-over-16s-diagnosis-andmanagement-pdf-66143839026373

https://www.nice.org.uk/guidance/qs87/resources/osteoarthritis-in-over-16s-pdf-2098913613253

https://www.nice.org.uk/guidance/ng226/evidence/e-clinical-and-cost-effectiveness-of-manual-therapy-for-the-management-of-osteoarthritis-pdf-11250452850

https://www.nice.org.uk/guidance/mtg76/resources/aposhealth-for-knee-osteoarthritis-pdf-64372240535749

Osteoarthritis | Arthritis UK

 

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Coventry Guidance  
Knee Pain (Adults)

Acute Knee Injury Pathway

 

Common acute knee injury differential diagnoses:

Ligament injury (most commonly anterior cruciate ligament)

Acute meniscus injury (non degenerative)

  • Recent twisting injury
  • Swelling (slower than in cruciate ligament rupture >1 hour)
  • May present with true locking or “giving way”
  • May have block to knee extension
  • Localised joint line pain and tenderness

Patella instability

Overload knee pain

  • Triggered by an increase in activity levels/ joint loading
  • No trauma/ injury as such
  • May have muscle weakness
  • Common in degenerative/ OA knee (not for acute knee clinic)

Referral to Acute Knee Clinic if below criteria satisfied:

  • Acute injury with instability (within last six weeks)
  • Significant injury, likely to require surgical intervention/use of a brace
  • Suspected ligament injury from history or examination
  • Suspected meniscal tear with locking (inability to fully extend)
  • First time traumatic patella dislocation

Acute Knee Clinic:

  • The Acute Knee Clinic is held every Thursday morning at Rugby St Cross
  • Contact the orthopaedic secretaries by phone, mark your referral letter “Urgent – Acute Knee Clinic”.
  • Alternatively, you can phone the consultant on duty in Fracture Clinic, open seven days a week.
  • These referrals can be sent through the NHS eReferral system, using the dedicated service (ACUTE- Trauma and Orthopaedics RAS- (Shoulder, Elbow, Hand, Wrist, Knee) UHCW- RKB).

Please note this service is not for degenerative knee conditions

Referrals will be reviewed by a Clinician and an appointment will be allocated to the patient or in some circumstances the referral may be redirected to a more suitable service

Referral to routine elective knee clinic if below criteria satisfied (chronic soft tissue knee conditions (> 6-8 weeks old)

  • Chronic instability impacting on patient’s functional ability, refractory to GP and self-management
  • Suspected meniscal injury – symptoms interfere with the ability to work or persist despite 6–8 weeks of rehabilitation by a physiotherapist
  • Suspected medial or lateral collateral ligament injury – symptoms interfere with the ability to work or persist despite 4–6 weeks of rehabilitation by a physiotherapist
  • Suspected ACL injury impacting functional ability or intention to return to pivoting sports, e.g. football, rugby, netball, squash etc.
  • Suspected PCL injury impacting functional ability
  • Suspected meniscal injury impacting functional ability
  • Recurrent patella dislocation
  • Patient amenable to surgical intervention where relevant

Non-traumatic Knee Pain Pathway

Red Flags

Septic arthritis

  • Acute hot, painful, swollen knee +/-
  • Skin discolouration
  • Fever
  • Feeling unwell
  • Recent surgery
  • Requires immediate A+E referral

Spontaneous Osteonecrosis of Knee (SONK)

  • Minimal/ no trauma
  • Constant severe pain
  • Increased with weight bearing
  • Night pain
  • Most commonly affects females > 55
  • Medial condyle most affected

Rheumatological (gout/ pseudogout)

  • See rheumatology homepage
  • FBC, ESR, CRP, RA screen, anti CCP and uric acid
  • If rheumatological condition strongly suspected, consider urgent referral to rheumatology hot clinic 

Knee Osteoarthritis

GP management and self-management

For adult knee pain where likely diagnosis is osteoarthritis

Pharmacological management

  • Offer a topical non-steroidal anti-inflammatory drug (NSAID) for knee osteoarthritis as per drug formulary
  • Consider an oral NSAID if topical medicines are ineffective or unsuitable and offer a gastroprotective treatment alongside
  • Do not offer paracetamol or weak opioids routinely, unless used infrequently for short-term pain relief or all other treatments are ineffective or unsuitable

Exercise

  • Consider strengthening exercises to include gluteal, quads, hamstring and calf muscle strengthening
  • Encourage general aerobic fitness

Weight management (for people living with obesity or overweight):

  • Advise that weight loss will improve quality of life and physical function, and reduce pain
  • support them to choose a weight loss goal
  • Explain that any weight loss is likely to be beneficial but losing 10% is likely to be better than 5%.

Intra-articular corticosteroid injection:

  • Intra-articular steroid injection/s (moderate to severe pain) – most suitable for acute flare-up of pain and swelling
  • Consider intra-articular corticosteroid injections for short-term relief when other pharmacological treatments are ineffective or unsuitable or to support therapeutic exercise

Investigations:

Chronic knee pain – suspecting diagnosis of Osteoarthritis

  • Primary investigation OA series x-ray (not MRI)
  • Otherwise MSK physio service will decide on whether imaging is appropriate
  • If patient <40 with recent history of fever – consider FBC, ESR, CRP and urgent synovial fluid analysis

Anterior Knee Pain

Characteristics of anterior knee pain:

  • It is common (annual prevalence in general population males = 15.5% females = 29.2%
  • Pain is usually at the front of or all over knee
  • Often bilateral
  • Exacerbated by stairs/hills/squatting/sitting long time
  • Pseudo-mechanical symptoms (regular, transient)
  • Usually no history of injury

Primary care management of anterior knee pain:

  • Analgesics/NSAIDs, walking aid, weight management (especially if BMI >30)
  • Advise to stay active, continue low impact activities
  • Radiology usually not required
  • No need for MRI
  • Consider plain X-ray if age > 45
  • Consider referral to physiotherapy if no improvement after 6 weeks

 

Painful Arthroplasty Pathway

 

Post arthroplasty infection concern

If systemically well and procedure done locally to discuss with secretary of consultant (on discharge summary) to arrange urgent outpatient appointment.

If systemically unwell (raised temperature/ heart rate), or procedure not done locally to discuss with ortho SPR on call.

References:

Horga, L.M., Hirschmann, A.C., Henckel, J. et al. Prevalence of abnormal findings in 230 knees of asymptomatic adults using 3.0 T MRI. Skeletal Radiol 49, 1099–1107 (2020). https://doi.org/10.1007/s00256-020-03394-z

Smith BE, Selfe J, Thacker D, Hendrick P, Bateman M, Moffatt F, Rathleff MS, Smith TO, Logan P. Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis. PLoS One. 2018 Jan 11;13(1):e0190892. doi: 10.1371/journal.pone.0190892. PMID: 29324820; PMCID: PMC5764329.

Steroid Injections

Community Physiotherapy are now injecting all patients, both high and low risk, leaving 2 weeks before or after Covid vaccination

Steroid joint injections are not currently being performed at UHCW in Musculo-Skeletal / Orthopaedics / Radiology. Please do not currently refer to UHCW for this purpose

GP Gateway Information

Please note GP Gateway has separate pages on:

Knee Arthroscopy

Referral to Adult Physiotherapy Service – Coventry

If patients have ongoing musculoskeletal knee pain and have not improved with relative rest or analgesic advice, refer to the Adult Physiotherapy Service – Coventry. Here they will be assessed and treated with the following:

  • Advice and education
  • Specific Exercises
  • Classes – for Patello-Femoral Pain and Osteoarthritis of the knee
  • Manual therapy/ soft tissue technique
  • Provision of walking aids
  • Taping
  • Acupuncture
  • Injection – Blind or Ultrasound Guided – Intra-articular only. No soft tissue injections

 

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