Loose or redundant peri-anal skin
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Anal fissure is a benign tear in the ano-derm, the skin lining the lower half of the anal canal.
An anal fistula is an abnormal communication between the anal canal / lower rectum and the perineal, perianal or buttock skin
Some lower GI tract cancers are caused by inherited germline mutations.
Pilonidal sinus is a condition caused by chronic infection of abscess cavities, containing hair, in the natal cleft.